线粒体通路和呼吸控制

Mitochondrial pathways and respiratory control

Keywords：Q-junction, Respiratory states, Flux control ratios, Additivity, Body mass excess

关键词：Q-结，呼吸状态，通量控制比，可加性，体重过剩
作者：Erich Gnaiger

出版期刊：《Bioenerg Commun 2020.2》（2020年）

Abstract：

Did you know that keeping your mitochondria fit is essential for quality of life, brain and muscle function, and resistance against preventable, immunological, and age-related degenerative diseases?

The capacity of cellular oxidative phosphorylation (OXPHOS) — a direct measure of mitochondrial function — is a result of evolution, age, gender, lifestyle, and environment (EAGLE). Increasingly, western lifestyle and aging contribute to mitochondrial dysfunction and the current epidemic of preventable diseases, including neurodegenerative and cardiovascular diseases, obesity, diabetes, and various types of cancer. The mitObesity epidemic leads to multimorbidity in aging and threatens to overwhelm the capacity of healthcare systems.

Training in mitochondrial physiology and bioenergetics, therefore, has high relevance to society. The ‘Blue Book’ on Mitochondrial Pathways and Respiratory Control presents a fundamental introduction to OXPHOS analysis for students and researchers in life sciences ― from evolutionary biology to medical and environmental applications. It combines concepts of bioenergetics and biochemical pathways related to mitochondrial core energy metabolism, provides the basis for substrate-uncoupler-inhibitor titration (SUIT) protocols, and updates the terminology consistent with the MitoEAGLE white paper on Mitochondrial Physiology.

文章摘要：

细胞氧化磷酸化 (OXPHOS) 的能力 - 线粒体功能的直接衡量标准 - 是进化、年龄、性别、生活方式和环境 (EAGLE) 的结果。西方生活方式和衰老越来越多，导致线粒体功能障碍和当前流行的可预防疾病，包括神经退行性疾病和心血管疾病、肥胖症、糖尿病和各种癌症。 mitObesity 流行病导致老龄化中的多种疾病，并有可能使医疗保健系统的能力不堪重负。
因此，线粒体生理学和生物能量学培训与社会高度相关。关于线粒体途径和呼吸控制的“蓝皮书”为生命科学领域的学生和研究人员提供了 OXPHOS 分析的基本介绍——从进化生物学到医学和环境应用。它结合了与线粒体核心能量代谢相关的生物能量学和生化途径的概念，为底物-解偶联剂-抑制剂滴定 (SUIT) 协议提供了基础，并更新了与 MitoEAGLE 线粒体生理学白皮书一致的术语。

点击链接即可查看和下载文章：https://wiki.oroboros.at/images/e/ec/BEC_2020.2_doi10.26124bec2020-0002.pdf

文章题目、关键词与摘要译文仅用于参考。