在慢性暴露于烟雾的豚鼠的血小板中观察到线粒体功能异常 - a试验研究

Mitochondrial functioning abnormalities observed in blood platelets

of chronic smoke-exposed guinea pigs – a pilot study.

Keywords：Mitochondria, Electron leak, Proton leak, Electron transport chain, ETC, Chronic obstructive pulmonary disease, COPD, Animal model 

关键词：线粒体、电子泄漏、质子泄漏、电子传输链、ETC、慢性阻塞性肺病、COPD、动物模型
作者：Bialas AJ , Siewie K , Watala C , Rybicka A , Grobelski B , Kosmider L , Kurek J , Milkowska-Dymanowska J , Piotrowski WJ , Gorski P
出版期刊：《Int J Chron》（2018）

Abstract：

COPD represents a major global health issue, which is often accompanied by cardiovascular diseases. A considerable body of evidence suggests that cardiovascular risk is elevated by the activation of blood platelets, which in turn is exacerbated by inflammation. As reactive oxygen species are believed to be an important factor in platelet metabolism and functioning, the aim of our study was to perform a complex assessment of mitochondrial function in platelets in chronic smoke exposed animals with COPD-like lung lesions.

文章摘要：

慢性阻塞性肺病是一个全球性的重大健康问题,常伴有心血管疾病。大量证据表明，血小板活化会增加心血管风险，而炎症又会加剧血小板活化。由于活性氧被认为是血小板代谢和功能的重要因素，我们研究的目的是对患有 COPD 样肺损伤的慢性烟雾暴露动物的血小板中的线粒体功能进行复杂的评估。

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