断奶时改用标准食物可改善母体和产后高脂肪和高蔗糖饮食的效果成年雄性小鼠后代的心脏代谢健康

Switching to a standard chow diet at weaning improves the effects of maternal and postnatal

high-fat and high-sucrose diet on cardiometabolic health in adult male mouse offspring.

Keywords：Diabetes, Glucose and insulin tolerance tests, Male mouse offspring, Obesity, Systolic function 

关键词：糖尿病、葡萄糖和胰岛素耐量测试、雄性小鼠后代、肥胖、收缩功能 
作者：Chiñas Merlin A, Gonzalez K, Mockler S, Perez Y, Jia UA, Chicco AJ, Ullevig SL, Chung E

出版期刊：《Metabolites》（2022）

Abstract：

Cardiac mitochondrial dysfunction contributes to obesity-associated heart disease. Maternal and postnatal diet plays an important role in cardiac function, yet the impacts of a mismatch between prenatal and postweaning diet on cardiometabolic function are not well understood. We tested the hypothesis that switching to a standard chow diet after weaning would attenuate systemic metabolic disorders and cardiac and mitochondrial dysfunction associated with maternal and postnatal high-fat/high-sucrose (HFHS) diet in mice. Six-month-old male CD1 offspring from dams fed a HFHS diet and weaned to the same HFHS diet (HH) or switched to a standard chow diet (HC) were compared to offspring from dams fed a low-fat/low-sucrose diet and maintained on the same diet (LL). HC did not decrease body weight (BW) but normalized glucose tolerance, plasma cholesterol, LDL, and insulin levels compared to the HH. Systolic function indicated by the percent fractional shortening was not altered by diet. In freshly isolated cardiac mitochondria, maximal oxidative phosphorylation-linked respiratory capacity and coupling efficiency were significantly higher in the HC in the presence of fatty acid substrate compared to LL and HH, with modification of genes associated with metabolism and mitochondrial function. Switching to a standard chow diet at weaning can attenuate the deleterious effects of long-term HFHS in adult male mouse offspring.

文章摘要：

心脏线粒体功能障碍会导致肥胖相关的心脏病。产妇和产后饮食在心脏功能中起着重要作用，但产前和断奶后饮食不匹配对心脏代谢功能的影响尚不清楚。我们检验了这样一个假设，即断奶后改用标准食物会减轻与小鼠母体和产后高脂肪/高蔗糖 (HFHS) 饮食相关的全身代谢紊乱以及心脏和线粒体功能障碍。将喂食 HFHS 饮食并断奶到相同 HFHS 饮食 (HH) 或改用标准食物 (HC) 的水坝的六个月大的雄性 CD1 后代与喂食低脂肪/低蔗糖饮食的水坝的后代进行比较并保持相同的饮食（LL）。与 HH 相比，HC 并未降低体重 (BW)，但使葡萄糖耐量、血浆胆固醇、LDL 和胰岛素水平正常化。由缩短百分比表示的收缩功能未因饮食而改变。在新鲜分离的心脏线粒体中，与 LL 和 HH 相比，在存在脂肪酸底物的情况下，HC 中的最大氧化磷酸化相关呼吸能力和耦合效率显着更高，并且与代谢和线粒体功能相关的基因发生了修饰。断奶时改用标准饲料可以减轻长期 HFHS 对成年雄性小鼠后代的有害影响。

点击链接即可查看和下载文章：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230726/pdf/metabolites-12-00563.pdf

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