PANK1与透明细胞肾细胞癌中的癌症代谢和免疫浸润有关：基于 TCGA 数据库的回顾性预后研究

PANK1 associates with cancer metabolism and immune infiltration in clear cell renal

cell carcinoma: a retrospective prognostic study based on the TCGA database.

Keywords：Clear cell renal cell carcinoma (ccRCC), Immune infiltration, Pantothenate kinase-1, Promoter methylation, Tumor metabolism

关键词：透明细胞肾细胞癌 (ccRCC)、免疫浸润、泛酸激酶-1、启动子甲基化、肿瘤代谢 
作者：Wang Bin, Liu Bin, Luo Qing, Sun Ding, Li Hao, Zhang Jie, Jin Xinye, Cheng Xiaowei, Niu Jingxue, Yuan Qing, Chen Yizhi
出版期刊：《Transl Cancer Res》（ 2022）

Abstract：

Identify key biomarkers to improve the clinical prognosis of patients with advanced and metastatic clear cell renal cell carcinoma (ccRCC) remains an important research topic. Recently, ccRCC has been regarded as a metabolic disease. Pantothenate kinase-1 (PANK1) has been shown to play an important regulatory role in global metabolism and associates with the pathogenesis of hepatocellular carcinoma. Therefore, we aimed to investigate the role of PANK1 in the prognosis of ccRCC and in metabolism and immunity.
 

文章摘要：

确定关键生物标志物以改善晚期和转移性透明细胞肾细胞癌 (ccRCC) 患者的临床预后仍然是一个重要的研究课题。最近，ccRCC被认为是一种代谢性疾病。泛酸激酶-1 (PANK1) 已被证明在全球代谢中发挥重要的调节作用，并与肝细胞癌的发病机制相关。因此，我们旨在研究PANK1在ccRCC预后以及代谢和免疫中的作用。

点击链接即可查看和下载文章：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372198/pdf/tcr-11-07-2321.pdf

文章题目、关键词与摘要译文仅用于参考。