线粒体参与严重学龄前喘息者的支气管平滑肌重塑

Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers.

Keywords：Asthma; Bronchial Remodeling; Calcium; Children; Mitochondrial Biogenesis.

关键词：哮喘；支气管重塑; 钙; 孩子们; 线粒体生物发生

哺乳动物：人
作者：Beaufils Fabien、Esteves Pauline、Enaud Raphaael、Germande Ophelie、Celle Alexis、Marthan Roger、Trian Thomas、Fayon Michael、Berger Patrick
出版期刊：《J Allergy Clin Immunol》（2021）

Abstract：

Bronchial remodeling is a key feature of asthma that is already present in preschoolers with wheezing. Moreover, bronchial smooth muscle (BSM) remodeling at preschool age is predictive of asthma at school age. However, the mechanism responsible for BSM remodeling in preschoolers with wheezing remains totally unknown. In contrast, in adult asthma, BSM remodeling has been associated with an increase in BSM cell proliferation related to increased mitochondrial mass and biogenesis triggered by an altered calcium homeostasis. Indeed, BSM cell proliferation was decreased in vitro by the calcium channel blocker gallopamil.Our aim was to investigate the mechanisms involved in BSM cell proliferation in preschoolers with severe wheezing, with special attention to the role of mitochondria and calcium signaling.

文章摘要：

支气管重塑是哮喘的一个关键特征，已经存在于患有喘息的学龄前儿童中。此外，学龄前支气管平滑肌 (BSM) 重塑可预测学龄期哮喘。然而，学龄前儿童喘息的 BSM 重塑的机制仍然完全未知。相比之下，在成人哮喘中，BSM 重塑与 BSM 细胞增殖增加有关，这与由改变的钙稳态引发的线粒体质量和生物发生增加有关。事实上，钙通道阻滞剂加洛帕米 在体外降低了 BSM 细胞增殖。我们的目的是研究严重喘息学龄前儿童 BSM 细胞增殖的机制，特别关注线粒体和钙信号传导的作用。

点击链接即可查看和下载文章：https://www.jacionline.org/action/showPdf?pii=S0091-6749%2821%2900549-2

文章题目、关键词与摘要译文仅用于参考。