缺氧的ABC——什么是常态

The ABC of hypoxia – what is the norm

Keywords：ambient; anoxia; critical O2 pressure pc; functional hypoxia; hyperoxia; hypoxia; limiting O2 pressure pl; normoxia; oxygen O2; O2 concentration cO2 [µM]; partial O2 pressure pO2 [kPa]

关键词：周围环境；缺氧；临界氧压PC；功能性缺氧；高氧血症；低氧；极限氧压pl；常氧；氧气；氧气浓度二氧化碳[微米]；氧分压pO2[千帕]
作者：Donnelly Chris、Schmitt Sabine、Cecatto Cristiane、Cardoso Luiza HD、Komlodi Timea、Place Nicolas、Kayser Bengt、Gnaiger Erich

出版期刊：《MitoFit Preprints》（2022年7月15日）

Abstract：

Hypoxia is a condition of oxygen levels below normoxia and opposite to hyperoxia. We here define the normoxic reference state by three complementary precepts: (A) ambient normoxia at sea level in the contemporary atmosphere and corresponding dissolved O2 concentration at air saturation of aqueous environments; (B) biological compartmental O2 levels at ambient normoxia under physiological activity of healthy organisms in the absence of environmental stress (e.g. in a diving human, a stranded whale, a thermally stressed animal); and (C) O2 levels above the control region, i.e., where the capacity for O2 consumption is not compromised by partial O2 pressure as evaluated by its kinetics. Conversely, the abc of hypoxia is concerned with deviations from these reference points caused by different mechanisms: (a) ambient alterations of oxygen levels; (b) biological O2 demand exceeding O2 supply under pathological or experimental limitations of convective O2 transport or O2 diffusion; and (c) critical oxygen pressure in oxygen kinetics shifted by pathological and toxicological effects or environmental stress. The ABC of hypoxia may be of help in the design and interpretation of in vitro and in vivo experimental studies.

文章摘要：

缺氧是氧水平低于常氧并与高氧相反的情况。我们在这里通过三个互补的规则来定义常氧参考状态：(A) 现代大气中海平面的环境常氧量和水环境空气饱和时相应的溶解氧浓度； (B) 在没有环境压力的情况下，在健康生物体的生理活动下（例如，在潜水的人、搁浅的鲸鱼、热应激动物中），环境常氧下的生物区室 O2 水平； (C) 高于控制区域的 O2 水平，即 O2 消耗量不受其动力学评估的 O2 分压的影响。相反，缺氧的 abc 与不同机制引起的这些参考点的偏差有关：(a) 氧气水平的环境变化； (b) 在对流 O2 传输或 O2 扩散的病理或实验限制下，生物 O2 需求超过 O2 供应； (c) 氧气动力学中的临界氧气压力因病理和毒理学影响或环境压力而改变。缺氧 ABC 可能有助于体外和体内实验研究的设计和解释。

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文章题目、关键词与摘要译文仅用于参考。