线粒体移植对大鼠盲肠浆模型的免疫调节作用

The immune modulatory effects of mitochondrial transplantation on cecal slurry model in rat.

Keywords：Sepsis, Immune modulation, Hyperinfammation, Immune paralysis, Mitochondria transplantation,Mitochondria dysfunction

关键词：脓毒症，免疫调节，过度炎症，免疫麻痹，线粒体移植，线粒体功能障碍
作者：Hwang JW, Lee MJ, Chung TN, Lee HAR, Lee JH, Choi SY, Park YJ, Kim CH, Jin I, Kim SH, Kwak HB, Heo JW, Na K, Choi S, Choi YS, Kim K

出版期刊：《Crit Care》（2021）

Abstract：

Sepsis has a high mortality rate, but no specifc drug has been proven efective,Recently, mitochondrial transplantation has emerged as a treatment modality for various diseases involving mitochondrial dysfunction, but it has never been tested for sepsis. We isolated mitochondria from L6 muscle cells and umbilical cord mesenchymal stem cells and tested the quality of the isolated mitochondria. We conducted both in vivo and in vitro sepsis studies. Mitochondrial transplantation improved survival and bacterial clearance. It also mitigated mitochondrial dysfunction and apoptosis in septic spleens and attenuated both hyperinfammation and immune paralysis in the spleens of cecal slurry model in rats. This efect was confrmed with an LPS-stimulated human PBMC study.

文章摘要：

脓毒症死亡率高，但尚无特定药物被证明有效。最近，线粒体移植已成为各种涉及线粒体功能障碍的疾病的治疗方式，但从未对败血症进行过测试。我们从 L6 肌肉细胞和脐带间充质干细胞中分离线粒体，并测试分离线粒体的质量。我们进行了体内和体外脓毒症研究，结果，线粒体移植提高了存活率和细菌清除率。它还减轻了脓毒症脾脏中的线粒体功能障碍和细胞凋亡，并减轻了大鼠盲肠浆液模型脾脏的过度炎症和免疫麻痹。这种效应通过 LPS 刺激的人类 PBMC 研究得到证实。在大鼠的多微生物盲肠浆模型中，线粒体移植可能是通过免疫调节作用来改善预后。

点击链接即可查看和下载文章：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789332/pdf/13054_2020_Article_3436.pdf

文章题目、关键词与摘要译文仅用于参考。