宫内生长受限兔模型的心脏和胎盘线粒体特征

Cardiac and placental mitochondrial characterization in a rabbit model of intrauterine growth restriction

Keywords：Cardiovascular function; Fetal growth; Mitochondrial complex II; Mitochondrial dysfunction; Rabbit animal model; Sirtuin3.

关键词：心血管功能； 胎儿生长; 线粒体复合物 II； 线粒体功能障碍; 兔动物模型； Sirtuin3.

哺乳动物：兔子

作者：Guitart-Mampel M, Gonzalez-Tendero A, Niñerola S, Morén C, Catalán-Garcia M, González-Casacuberta I, Juárez-Flores DL, Ugarteburu O, Matalonga L, Cascajo MV, Tort F, Cortés A, Tobias E, Milisenda JC, Grau JM, Crispi F, Gratacós E, Garrabou G, Cardellach F 

出版期刊：《BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES》 2018/2/13

Abstract：
Intrauterine growth restriction (IUGR) is associated with cardiovascular remodeling persisting into adulthood. Mitochondrial bioenergetics, essential for embryonic development and cardiovascular function, are regulated by nuclear effectors as sirtuins. A rabbit model of IUGR and cardiovascular remodeling was generated, in which heart mitochondrial alterations were observed by microscopic and transcriptomic analysis. We aimed to evaluate if such alterations are translated at a functional mitochondrial level to establish the etiopathology and potential therapeutic targets for this obstetric complication.

文章摘要：

宫内生长受限 (IUGR) 与持续到成年期的心血管重塑有关。线粒体生物能量学对胚胎发育和心血管功能至关重要，由核效应器作为 sirtuins 进行调节。建立了 IUGR 和心血管重塑的兔模型，其中通过显微镜和转录组分析观察到心脏线粒体的改变。我们的目的是评估这些改变是否在功能性线粒体水平上转化，以确定这种产科并发症的病因和潜在治疗靶点。
 

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