非活动期的限时喂养消除了大鼠骨骼肌线粒体呼吸的每日节律

Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle

Keywords：Slipidomics, metabolomics, mitochondrial respiration, soleus muscle, time- restricted feeding

关键词：脂质组学、代谢组学、线粒体呼吸、比目鱼肌、限时进食
作者：Stephanie R Heimler1*, Howard J Phang1*,Jaclyn Bergstrom1, Gargi Mahapatra2,Stephen Dozier1, Erich Gnaiger3,Anthony J A Molina1**
出版期刊：《FASEB Journal 》（2021）

Abstract：

Shiftwork impairs muscle mitochondrial functioning on multiple levels, which eventually could lead to metabolic disorders such as T2DM. Thus, our results suggest that mitochondria are an interesting therapeutic target for the prevention or even treatment of T2DM as they can be targeted not only by pharmaceutical drugs, but can also be influenced by lifestyle interventions. Examples of such lifestyle interventions are dietary interventions (both caloric restriction as well as
nutritional supplements such as resveratrol, carnitine,and NAD+ precursors) and (timed) exercise and other measures to strengthen circadian rhythms. Therefore,these interventions urgently need further confirmation
in human studies in the context of treatment and/or
prevention of T2DM,11 especially whether an optimized combination and timing of exercise and diet can further enhance their separate effects.

文章摘要：

轮班工作在多个水平上损害肌肉线粒体功能，最终可能导致代谢紊乱，如2型糖尿病。因此，我们的研究结果表明，线粒体是预防甚至治疗2型糖尿病的一个有趣的治疗靶点，因为它们不仅可以被药物靶向，而且还可以受到生活方式干预的影响。这种生活方式干预的例子是饮食干预(包括热量限制以及营养补充剂，如白藜芦醇、肉碱和NAD+前体)和（定时）运动和其他加强昼夜节律的措施。因此，这些干预措施迫切需要在治疗和/或预防的人类研究中进一步证实，特别是优化运动和饮食的组合和时间是否可以进一步增强它们的单独效果。

点击链接即可查看和下载文章：https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202100707R

文章题目、关键词与摘要译文仅用于参考。